ONCRN
Optic Neuritis
Collaborative Research Network
视神经炎研究协作网络
An investigator-led, ophthalmology-centered, multicenter collaborative research network focused on optic neuritis.
由研究者发起、以眼科和神经眼科为核心的视神经炎多中心研究协作网络。
ONCRN grew out of the multicenter collaboration established through GX-ICON (NCT07623252).
ONCRN源于GX-ICON多中心研究所形成的协作基础，并在参与中心眼科研究团队既有合作基础上逐步发展建立。
- Network Lead 网络负责人（组长）
- Yi Du, MD, PhD 杜毅，医学博士ResearchGate 个人学术主页 ↗
- Lead and Coordinating Institution 牵头及协调单位
- The First Affiliated Hospital of Guangxi Medical University 广西医科大学第一附属医院
The Optic Neuritis Collaborative Research Network (ONCRN) is an investigator-led, ophthalmology-centered, multicenter collaborative research network dedicated to advancing clinical and translational research in optic neuritis.
ONCRN grew out of the multicenter collaboration established through GX-ICON (NCT07623252), a prospective multicenter study evaluating the 2022 International Criteria for Optic Neuritis and an antibody-stratified adjunct diagnostic approach. The network developed from the collaborative research framework established among ophthalmology teams at participating centers.
ONCRN is currently centered on ophthalmologists and neuro-ophthalmologists, working in collaboration with colleagues in neurology, medical imaging, and related disciplines.
ONCRN focuses on diagnostic criteria, clinical phenotyping, etiological classification, antibody testing, OCT and MRI assessment, acute treatment, and treatment accessibility in optic neuritis.
ONCRN emphasizes rigorous methodology, standardized data collection, transparent collaboration, responsible data use, and clinically meaningful research. Its long-term aim is to address important questions in optic neuritis that are difficult for individual centers to answer reliably on their own.
关于ONCRN
视神经炎研究协作网络（Optic Neuritis Collaborative Research Network，ONCRN）是由研究者发起、以眼科和神经眼科为核心的多中心研究协作网络，主要围绕视神经炎开展临床及相关转化研究。
ONCRN源于GX-ICON（NCT07623252）多中心前瞻性研究所形成的协作基础。GX-ICON主要评价2022年国际视神经炎诊断标准及抗体分层辅助诊断路径，ONCRN在参与中心眼科研究团队既有协作基础上逐步发展建立。
ONCRN目前以眼科医生和神经眼科医生为核心，与神经内科、医学影像等相关学科开展协作。
ONCRN重点关注视神经炎的诊断标准、临床表型、病因分层、抗体检测、OCT与MRI评估、急性期治疗及治疗可及性等问题。
网络重视严谨的研究方法、规范的数据采集、透明的协作机制、负责任的数据使用以及具有临床意义的研究结果，重点解决单一中心难以可靠回答的重要视神经炎临床问题。
02 / Research
Research in optic neuritis围绕视神经炎的研究方向
ONCRN brings together ophthalmologists and neuro-ophthalmologists to study optic neuritis, in collaboration with colleagues in neurology, medical imaging, and related disciplines.
ONCRN以眼科医生和神经眼科医生为核心，联合神经内科、医学影像等相关学科开展视神经炎研究。
- Diagnosis and classification诊断与分类
- Diagnostic criteria, diagnostic accuracy, and etiological classification.诊断标准、诊断准确性及病因分层。
- Clinical phenotyping临床表型
- Clinical presentation and longitudinal characterization.临床表现及长期随访中的表型评估。
- Antibody testing抗体检测
- AQP4-IgG and MOG-IgG in the diagnostic context.诊断背景下的AQP4-IgG与MOG-IgG检测。
- OCT and MRIOCT与MRI
- Structural and imaging characterization of optic neuritis.视神经炎的结构及影像学评估。
- Acute treatment急性期治疗
- Acute attack treatment and escalation therapy.急性发作治疗及升级治疗。
- Treatment accessibility治疗可及性
- Access to treatment and its relationship to clinical outcomes.治疗可及性及其与临床结局的关系。
Optic neuritis across etiologies不同病因的视神经炎
The research scope includes AQP4-IgG-positive, MOG-IgG-associated, seronegative, and other clinically relevant optic neuritis phenotypes.
研究范围包括AQP4-IgG阳性、MOG-IgG相关、血清阴性及其他具有临床意义的视神经炎表型。
03 / GX-ICON
GX-ICON多中心研究协作基础
Prospective Evaluation of the 2022 International Criteria for Optic Neuritis and an Antibody-Stratified Adjunct Diagnostic Approach
2022年国际视神经炎诊断标准及抗体分层辅助诊断路径的前瞻性评价
A prospective multicenter observational diagnostic accuracy study. No experimental treatment is assigned by the study.
一项前瞻性多中心观察性诊断准确性研究，研究不分配试验性治疗。
ClinicalTrials.gov Identifier: NCT07623252 ↗
Registered study title / 登记研究标题
A Multicenter Prospective Diagnostic Accuracy Study of the 2022 International Criteria for Optic Neuritis and an Antibody-Stratified Adjunct in Acute or Subacute Visual Loss When Optic Neuritis Is Suspected in China
GX-ICON registry: ClinicalTrials.gov. Record checked on ; last update posted .
GX-ICON登记信息：ClinicalTrials.gov。核对日期：2026-09-23；记录最新公开更新日期：2026-06-15。
04 / Members
Member Institutions成员单位
Current member institutions of ONCRN are listed below.
以下为ONCRN目前成员单位。
Geographic distribution成员单位分布
9 institutions · 5 cities
9家成员单位 · 5座城市
Basemap unavailable. Hospital map links remain available below.
底图暂时无法加载，仍可通过下方链接查询医院位置。
City-level locations · Numbers indicate member institutions.
按所在城市标注，数字为成员单位数量。
- The First Affiliated Hospital of Guangxi Medical University广西医科大学第一附属医院Nanning, Guangxi · 广西南宁Map / 高德地图 ↗
- Wuzhou Gongren Hospital梧州市工人医院Wuzhou, Guangxi · 广西梧州Map / 高德地图 ↗
- The First People's Hospital of Yulin玉林市第一人民医院Yulin, Guangxi · 广西玉林Map / 高德地图 ↗
- The Second Affiliated Hospital of Guangxi Medical University广西医科大学第二附属医院Nanning, Guangxi · 广西南宁Map / 高德地图 ↗
- The Second People's Hospital of Qinzhou钦州市第二人民医院Qinzhou, Guangxi · 广西钦州Map / 高德地图 ↗
- Guangxi Minzu Hospital广西壮族自治区民族医院Nanning, Guangxi · 广西南宁Map / 高德地图 ↗
- Wuming Hospital of Guangxi Medical University广西医科大学附属武鸣医院Wuming, Nanning · 南宁武鸣Map / 高德地图 ↗
- Lixiang Eye Hospital of Soochow University苏州大学理想眼科医院Suzhou, Jiangsu · 江苏苏州Map / 高德地图 ↗
- Guangxi Jingliang Eye Hospital广西晶亮眼科医院Nanning, Guangxi · 广西南宁Map / 高德地图 ↗
05 / Leadership
Leadership负责人及协调单位
- Network Lead网络负责人（组长）
- Yi Du, MD, PhD杜毅，医学博士ResearchGate 个人学术主页 ↗
- Lead and Coordinating Institution牵头及协调单位
- The First Affiliated Hospital of Guangxi Medical University广西医科大学第一附属医院